Research grade

COA available

Research Peptide

TB-500 5mg

Thymosin Beta-4 synthetic fragment — 43 amino acids with LKKTETQ actin-binding motif Published in Nature and The FASEB Journal — extensively studied actin-regulating peptide CAS 77591-33-4 For in vitro cell migration and actin research only

$37.99 In stock

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For laboratory research use only. Not for human or veterinary consumption. SKU TB5.

Overview

Product details.

TB-500 5mg — Thymosin Beta-4

Thymosin Beta-4 is found in nearly every mammalian cell type — platelets, white blood cells, wound fluid. It is one of the most conserved actin-regulating proteins in nature. TB-500 is the synthetic form: all 43 amino acids, including the critical LKKTETQ motif at positions 17-23 that gives it high-affinity actin binding. Published research on this compound spans Nature, The FASEB Journal, and The Journal of Investigative Dermatology.

Research-Grade Compounds

Manufactured to research-grade standards for laboratory research use only.

Discreet Shipping

Every order ships in plain, protective packaging.

In-House Fulfillment

Orders are inspected, packed, and shipped directly by the Heritage Labs team.

Specifications

Full Sequence	Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Active Region	LKKTETQ (amino acids 17-23)
Molecular Formula	C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight	4963.44 g/mol
CAS Number	77591-33-4
PubChem CID	16132042
Form	Lyophilized powder
Quantity	5mg per vial

The research record

Malinda et al. reported a 41% increase in re-epithelialization within 4 days in full-thickness dermal wound models, concluding that “Tβ4 is a potent wound healing factor with multiple activities” (J Investigative Dermatology, 1999; PubMed 10469335).

Bock-Marquette et al. published findings in Nature showing enhanced cardiomyocyte migration and survival through integrin-linked kinase (ILK) and Akt signaling activation in myocardial infarction models (Nature, 2004; PubMed 15565145).

Philp et al. characterized angiogenesis and directional cell migration in both normal and aged rodent models through endothelial tube formation and ECM remodeling (Annals NYAS, 2004; PubMed 15037013).

Goldstein et al. reviewed NF-κB signaling modulation, pro-inflammatory cytokine reduction, and decreased inflammatory cell infiltration in tissue models (Expert Opinion on Biological Therapy, 2012; PubMed 22074294).

TB-500 vs BPC-157

Different mechanisms for different systems. TB-500 research centers on actin regulation, cell migration, blood vessel formation, and cardiac tissue. BPC-157 research centers on gastrointestinal integrity, connective tissue, and nitric oxide pathways. Published protocols treat them as complementary, not interchangeable. Heritage Labs USA offers both individually and as a BPC-TB blend.

Research applications

Cell migration and wound closure assays
Actin polymerization dynamics and G-actin/F-actin equilibrium
Angiogenesis pathway screening
ECM remodeling and collagen expression
Inflammatory signaling profiling
Cardiac cell survival and ILK activation

Frequently paired with

BPC-157 5mg — Available as BPC-TB Blend.
GHK-Cu 50mg — Available in Glow 50/10/10.

Quality and testing

Every Heritage Labs compound is manufactured to research-grade standards and shipped in protective packaging.

Storage

Lyophilized: -20°C (up to 12 months sealed)
Reconstituted: 2-8°C, use within 30 days
Protection: Shield from light and moisture; avoid freeze-thaw cycles
Handling: Let the vial reach room temperature before opening to prevent condensation

References

Malinda KM, et al. J Investigative Dermatology. 1999;113(3):364-368. PubMed 10469335
Bock-Marquette I, et al. Nature. 2004;432(7016):466-472. PubMed 15565145
Philp D, et al. Annals NYAS. 2004;1012:44-52. PubMed 15037013
Goldstein AL, et al. Expert Opinion on Biological Therapy. 2012;12(1):37-51. PubMed 22074294
Kleinman HK, Sosne G. Vitamins and Hormones. 2016;102:251-275. PubMed 27450738

FAQ

What is TB-500?

A synthetic 43-amino-acid peptide corresponding to Thymosin Beta-4, an endogenous actin-sequestering protein. Subject of extensive preclinical research in wound repair, cardiac tissue, inflammation, and cell migration.

TB-500 vs Thymosin Beta-4?

Same molecule. TB-500 is the synthetic research-grade form of the naturally occurring protein. The terms are interchangeable in the literature.

Is TB-500 approved for human use?

No. TB-500 is a research compound, not approved by the FDA for any human use. Heritage Labs USA products are strictly for laboratory research.

For laboratory research use only. Not for human or veterinary use. Not a drug, food, or cosmetic.

For laboratory research use only. Not for human or veterinary use. This product is not a drug or supplement and is not intended to diagnose, treat, cure, or prevent any disease.

FDA Disclaimer. All products are for research use only (RUO) as defined by the FDA — not for diagnostic, human, or veterinary use. These products have not been evaluated and have not been approved by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.

Heritage Labs is a chemical supplier providing products strictly for laboratory research, analytical, and in-vitro purposes; it is not a compounding pharmacy or compounding facility under Section 503A, nor an outsourcing facility under Section 503B, of the Federal Food, Drug, and Cosmetic Act.